In 2020, more than 24,500 fatalities in the U.S. were attributed to homicide incidents.  The five-state Great Lakes region accounted for over 4,100 homicide deaths in 2020, or about 16.8% of all homicides in the U.S. that year.  The region's homicide rate of 8.8 deaths per 100,000 population was the second highest regionally in the U.S., with only the Southeast recording a higher homicide death rate.  A closer study of state-level data from the CDC's National Center for Health Statistics provides the following details about homicide rates in the Great Lakes region:

Homicide Rates in the Great Lakes Region

State	Deaths	Population	Death Rate*
IL	1,353	12,587,530	10.7
IN	620	6,754,953	9.2
MI	811	9,966,555	8.1
OH	1,004	11,693,217	8.6
WI	334	5,832,655	5.7
Region	4,122	46,834,910	8.8
U.S.	24,576	329,484,123	7.5

(*) number of homicide deaths per 100,000 population

Report Period: 2020

Source: CDC Wonder. Centers for Disease Control and Prevention, National Center for Health Statistics. Underlying Cause of Death 1999-2020 on CDC WONDER Online Database, released in 2021. Data are from the Multiple Cause of Death Files, 1999-2020, as compiled from data provided by the 57 vital statistics jurisdictions through the Vital Statistics Cooperative Program. Accessed on April 25, 2022