There were 696,962 deaths in the United States in 2020 that were attributable to heart disease. Given the size of the U.S. population, that translated to a heart disease death rate of 211.5 deaths per 100,000 population. Analysis of data from the CDC's National Center for Health Statistics provides the following details about regional heart disease death rates in the U.S.  Follow the "region" links in the table below to see state-level data within each region:

Regional Heart Disease Death Rates in the U.S.

Region	Deaths	Population	Death Rate*
Far West	96,816	56,579,620	171.1
Great Lakes	112,944	46,834,910	241.2
Great Plains	45,060	21,481,834	209.8
Mid-Eastern	117,371	48,757,828	240.7
New England	28,580	14,847,468	192.5
Rocky Mountain	19,063	12,547,416	151.9
Southeastern	196,674	85,565,785	229.9
Southwestern	80,454	42,869,262	187.7
U.S.	696,962	329,484,123	211.5

(*) number of heart disease deaths per 100,000 population

Report Period: 2020

Source: CDC Wonder. Centers for Disease Control and Prevention, National Center for Health Statistics. Underlying Cause of Death 1999-2020 on CDC WONDER Online Database, released in 2021. Data are from the Multiple Cause of Death Files, 1999-2020, as compiled from data provided by the 57 vital statistics jurisdictions through the Vital Statistics Cooperative Program.