Homicides accounted for more than 24,500 deaths in the United States in 2020.  A closer examination of data from the CDC's National Center for Health Statistics provides the following details about U.S. homicide rates by region (to see state level data, follow the "Region" links in the table below):

U.S. Homicide Rates by Region

Region	Deaths	Population	Death Rate*
Far West	3,165	56,579,620	5.6
Great Lakes	4,122	46,834,910	8.8
Great Plains	1,460	21,481,834	6.8
Mid-East	3,153	48,757,828	6.5
New England	413	14,847,468	2.8
Rocky Mountain	563	12,547,416	4.5
Southeast	8,405	85,565,785	9.8
Southwest	3,295	42,869,262	7.7
U.S. Total	24,576	329,484,123	7.5

(*) number of homicide deaths per 100,000 population

Report Period: 2020

Source: CDC Wonder. Centers for Disease Control and Prevention, National Center for Health Statistics. Underlying Cause of Death 1999-2020 on CDC WONDER Online Database, released in 2021. Data are from the Multiple Cause of Death Files, 1999-2020, as compiled from data provided by the 57 vital statistics jurisdictions through the Vital Statistics Cooperative Program. Accessed on May 21, 2022