Women accounted for 314,186 of the nearly 697,000 heart disease deaths in the United States in 2020.  At 187.9 deaths per 100,000 population, the heart disease death rate for females in the U.S. in 2020 was about 20% lower than the male rate and  11.1% lower than the overall national heart disease death rate.  At the regional level, the female heart disease death rate was lowest in the five-state Rocky Mountain region and the highest in the Mid-Eastern U.S., a region that includes the District of Columbia and five states.  A closer examination of data from the CDC's National Center for Health Statistics provides the following details about female heart disease rates in the U.S. by region (follow the "region" links below for female heart disease death rate information at the state level within each region):

Female Heart Disease Death Rates in the U.S. by Region

Region	Deaths	Population	Death Rate*
Far West	54,932	28,192,091	194.8
Great Lakes	51,675	23,773,455	217.4
Great Plains	20,501	10,807,995	189.7
Mid-East	56,010	25,009,994	224.0
New England	13,193	7,604,537	173.5
Rocky Mountain	8,470	6,226,673	136.0
Southeast	87,506	43,829,093	199.7
Southwest	34,947	21,588,645	161.9
U.S. Female Only	314,186	167,227,921	187.9
U.S. Male Only	382,776	162,256,202	235.9
U.S. Total	696,962	329,484,123	211.5

(*) number of heart disease deaths per 100,000 population

Report Period: 2020

Source: CDC Wonder. Centers for Disease Control and Prevention, National Center for Health Statistics. Underlying Cause of Death 1999-2020 on CDC WONDER Online Database, released in 2021. Data are from the Multiple Cause of Death Files, 1999-2020, as compiled from data provided by the 57 vital statistics jurisdictions through the Vital Statistics Cooperative Program. Accessed on April 22, 2023