Of the more than 24,500 homicide deaths in the United States in 2020, male victims accounted for 19,958 of the total.  At 12.3 deaths per 100,000 population, the male homicide rate in the U.S. in 2020 was more than four (4) times higher than the female homicide rate and it was 64% higher than the overall national homicide rate.  At the regional level, New England had the lowest male homicide rate while the Southeastern U.S. had the highest.  A deeper look into data from the National Center for Health Statistics provides the following details about male homicide rates in the U.S. by region:

Male Homicide Rates in the U.S. by Region

Region	Deaths	Population	Death Rate*
Far West	2,580	28,192,091	9.2
Great Lakes	3,389	23,061,455	14.7
Great Plains	1,160	10,673,839	10.9
Mid-East	2,644	23,747,834	11.1
New England	339	7,242,931	4.7
Rocky Mountain	427	6,320,743	6.8
Southeast	6,807	41,736,692	16.3
Southwest	2,612	21,280,617	12.3
U.S. Male Only	19,958	162,256,202	12.3
U.S. Female Only	4,618	167,227,921	2.8
U.S. Total	24,576	329,484,123	7.5

(*) number of homicide deaths per 100,000 population

Report Period: 2020

Source: CDC Wonder. Centers for Disease Control and Prevention, National Center for Health Statistics. Underlying Cause of Death 1999-2020 on CDC WONDER Online Database, released in 2021. Data are from the Multiple Cause of Death Files, 1999-2020, as compiled from data provided by the 57 vital statistics jurisdictions through the Vital Statistics Cooperative Program. Accessed on March 8, 2023