Female victims accounted for 4,618 of the more than 24,500 homicide deaths in the United States in 2020.  At 2.8 deaths per 100,000 population, the female homicide rate in the U.S. in 2020 was 77% lower than the male homicide rate and  62% lower than the overall national homicide rate.  At the regional level, the female homicide rate was lowest in New England and the highest in the Southeastern U.S.  A closer examination of data from the CDC's National Center for Health Statistics provides the following details about female homicide rates in the U.S. by region:

Female Homicide Rates in the U.S. by Region

Region	Deaths	Population	Death Rate*
Far West	585	28,387,529	2.1
Great Lakes	733	23,773,455	3.1
Great Plains	300	10,807,995	2.8
Mid-East	509	25,009,994	2.0
New England	74	7,604,537	1.0
Rocky Mountain	136	6,226,673	2.2
Southeast	1,598	43,829,093	3.6
Southwest	683	21,588,645	3.2
U.S. Female Only	4,618	167,227,921	2.8
U.S. Male Only	19,958	162,256,202	12.3
U.S. Total	24,576	329,484,123	7.5

(*) number of homicide deaths per 100,000 population

Report Period: 2020

Source: CDC Wonder. Centers for Disease Control and Prevention, National Center for Health Statistics. Underlying Cause of Death 1999-2020 on CDC WONDER Online Database, released in 2021. Data are from the Multiple Cause of Death Files, 1999-2020, as compiled from data provided by the 57 vital statistics jurisdictions through the Vital Statistics Cooperative Program. Accessed on March 8, 2023