In 2019, over 74,500 drug induced deaths were recorded in the United States, or about 22.7 deaths per 100,000 population. About 95% of these fatalities stemmed from drug overdoses, both accidental and intentional. Nationally, from 1999 to 2019 the annual drug induced death count increased by over 50,000 and the drug induced death rate per 100,000 population more than tripled. While every region of the country experienced an increase in its annual drug induced death count over the twenty years from 1999 to 2019, five regions of the country experienced a worse trend than the nation as whole. In fact, the drug induced death rate per 100,000 population more than quadrupled from 1999 to 2019 in the New England, Southeastern, Great Lakes, and Great Plains regions. A closer study of data from the Centers for Disease Control and Prevention, National Center for Health Statistics, produced the following details about U.S. drug induced deaths by region (to see state level data, follow the "Area" links in the table below) :
| Area/Deaths | 1999 | 2009 | 2019 |
| Far West | 4,391 | 6,733 | 9,950 |
| Great Lakes | 2,602 | 6,087 | 12,833 |
| Great Plains | 698 | 2,050 | 3,704 |
| Mid-East | 3,678 | 5,088 | 14,338 |
| New England | 1,066 | 1,892 | 4,840 |
| Rocky Mountain | 722 | 1,683 | 2,246 |
| Southeast | 3,700 | 10,851 | 19,917 |
| Southwest | 2,271 | 4,763 | 6,683 |
| Total | 19,128 | 39,147 | 74,511 |
| Area/Death Rate* | 1999 | 2009 | 2019 |
| Far West | 9.4 | 12.9 | 17.6 |
| Great Lakes | 5.8 | 13.1 | 27.4 |
| Great Plains | 3.6 | 10.1 | 17.3 |
| Mid-East | 8.0 | 10.6 | 29.3 |
| New England | 7.7 | 13.1 | 32.6 |
| Rocky Mountain | 7.9 | 15.6 | 18.1 |
| Southeast | 5.4 | 13.9 | 23.5 |
| Southwest | 7.4 | 12.9 | 15.8 |
| Total | 6.9 | 12.8 | 22.7 |
(*) number of drug induced deaths per 100,000 population
Source: CDC Wonder. Centers for Disease Control and Prevention, National Center for Health Statistics. Underlying Cause of Death 1999-2019 on CDC WONDER Online Database, released in 2020. Data are from the Multiple Cause of Death Files, 1999-2019, as compiled from data provided by the 57 vital statistics jurisdictions through the Vital Statistics Cooperative Program. Accessed on June 5, 2021
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