In 2020, 602,350 deaths in the United States were attributed to cancer. In the seven-state Great Plains region, cancer accounted for 41,272 deaths in 2020, about 7% of all cancer deaths in the U. S. that year. At 192.1 deaths per 100,000 population, the Great Plains region had a cancer death rate in 2020 that was about 5% above the national average. Further examination of data from the National Center for Health Statistics reveals the following state-level details about cancer death rates in the Great Plains region:
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Cancer Death Rates in the Great Plains Region | 
| State | Deaths | Population | Death Rate* | 
| Iowa | 6,304 | 3,163,561 | 199.3 | 
| Kansas | 5,538 | 2,913,805 | 190.1 | 
| Minnesota | 9,944 | 5,657,342 | 175.8 | 
| Missouri | 12,907 | 6,151,548 | 209.8 | 
| Nebraska | 3,541 | 1,937,552 | 182.8 | 
| North Dakota | 1,308 | 765,309 | 170.9 | 
| South Dakota | 1,730 | 892,717 | 193.8 | 
| Region | 41,272 | 21,481,834 | 192.1 | 
| U.S. | 602,350 | 329,484,123 | 182.8 | 
(*) number of cancer deaths per 100,000 population
Report Period: 2020
Source: CDC Wonder. Centers for Disease Control and Prevention, National Center for Health Statistics. Underlying Cause of Death 1999-2020 on CDC WONDER Online Database, released in 2021. Data are from the Multiple Cause of Death Files, 1999-2020, as compiled from data provided by the 57 vital statistics jurisdictions through the Vital Statistics Cooperative Program. Accessed on June 11, 2022

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